Without his memories, Weather saw Pucci as just an important enemy to defeat, but upon having his memories returned, Weather resumes his revenge on Pucci, nearly killing him before being distracted by Jolyne, leading to Pucci killing him. When Weather attempted revenge, Pucci removed his Memory disc. Pucci impulsively and unknowingly ruined his and their sister, Perla's, lives via a lynch by a corrupt Klansman cop, leading to the latter's death.

Weather Report has the most personal grudge of the heroes, due to Pucci and himself being revealed as long-lost twins.

He had created her to be his guard dog, but when she develops gratitude and a sense of justice with Jolyne, she personally challenges him in order to get even with him, even if it leads to her death.

From Jotaro's perspective, Pucci's use of Jolyne as bait and later placing a Sadistic Choice onto the man to either kill him or save Jolyne made him a very personal enemy. He targets Jotaro to both gain the information of Dio's Heaven plan in his Memory disc, as well as revenge for the loss of his comrade, Dio, which he would later fully commit when he kills Jotaro along with his daughter. and Weather Report, culminating in him personally killing her along with the rest of her comrades except for Emporio. It becomes more personal as he kills F.F. Her initial mission is to retrieve her father's Stand and Memory discs, as well as killing Pucci.

Jolyne Cujoh, whom he had set up to be imprisoned in order to lure her father as bait.

It becomes even more personal as he personally kills every single one of the comrades he's gained, leading to the boy killing the man himself.

Emporio, whose mother was killed by Pucci via taking her Stand disc in his effort to build up his arsenal to fight the Joestars and set up the Heaven plan.

Arch-Enemy: Pucci, in spite of his well-intentions, has managed to earn the ire of the majority of the heroes.

A big part of it is that he doesn't perceive himself as being amoral and thus isn't prone to being a Jerkass. When he gets pissed, it's usually because he's being pushed or, by the end of the series, has become deranged, and he doesn't bother to hide it.

Affably Evil: In a bit of a departure for the series' main villains (barring Kira and perhaps Dio on a good day), Pucci is pretty good-humored and his politeness is genuine.

Adaptational Dye-Job: In the manga, his robe mostly has a purple coloring.

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